Research interests

Development and application of advanced NMR approaches:

• Liquid phase NMR spectroscopy
- Structural analysis and stereochemistry of synthetic organic compounds
- Molecular mobility - classical dynamic NMR for the investigation of tautomeric and conformational equilibria.
- Diffusion NMR spectroscopy - investigation of supramolecular complexes, processes of self-aggregation, particle size determination in colloidal systems, analysis of complex mixtures.
- Chemical profiling and metabolic analysis of extracts of plant origin
- Analysis of food and natural products
- NMR spectroscopy with in situ irradiation

• Solid state NMR spectroscopy
- Structure of mesoporous silicates and zeolites
- Organic-inorganic hybrid materials

• NMR spectroscopy of soft materials - Polymeric (hydro)gels
- Extracts of medicinal and aromatic plants

LABORATORY MEMBERS

Head:

Prof. Dr. Pavletta Shestakova

02 9606 136

209

psd@orgchm.bas.bg

Name	Room	Phone	Е-mail*
Prof. Pavletta Shestakova, PhD, Head	209	136	psd
Prof. Nikolay Vassilev, PhD	112	172	niki
Prof. Svetlana Simova, DSc	104	140	sds
Assist. Prof. Alexander Kantardjiev, PhD	117	189	alexkant
Assist. Prof. Miroslav Dangalov, PhD	112	172	m.dangalov
Assist. Prof. Yavor Mitrev, PhD	106	146	yavor
Dessislava Gerginova, Phd student	103	120	dpg

Projects

Selected group publications(Q1)

2019

Eur. J. Pharm. Biopharm,
142,
460-472

Verapamil delivery systems on the basis of mesoporous ZSM-5/KIT-6 and ZSM-5/SBA-15 polymer nanocomposites as a potential tool to overcome MDR in cancer cells

Bioorg. Chem.,
90,
103028

Discovery of novel indole-based aroylhydrazones as anticonvulsants: Pharmacophore-based design

J. Mol. Liq.,
292,
111392

Tautomerism in folic acid: Combined molecular modelling and NMR study

Angew. Chem. Int. Ed.,
58,
5

Reactive Dimerization of an N-Heterocyclic Plumbylene: C-H Activation with PbII

Bioorg. Chem.,
85,
487-497

Anti-enteroviral activity of new MDL-860 analogues: Synthesis, in vitro/in vivo studies and QSAR analysis

Polym. Int.,
68,
9

Polyzwitterionic hydrogels as wound dressings with enzymatic debridement functionality for highly exuding wounds

ChemSusChem, 11,
10,
1612-1616

Going Beyond the Limits of the Biorenewable Platform: Unprecedented Sodium Dithionite Promoted Stabilization of 5-Hydroxymethylfurfural

Food and Chemical Toxicology, 111,
605-615

New iridoids from Verbascum nobile and their effect on lectin-induced T cell activation and proliferation

Applied Catalysis A: General, 560,
119-131

Efficient solid acid catalysts based on sulfated tin oxides for liquid phase esterification of levulinic acid with ethanol.