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Research gate project: ESIPT, and Fluoroborates - theory and experiment, see NSF project H09/39; 2016


Linked to the currently running


Current NSF project: H19/53 - 2017, Novel Intramolecular Proton Transfer

Heterocyclic Luminophores and Their Complexes for Modern Biomedicine

Contract # ДН 19/11, Dec. 10, 2017; Coordinator: Assoc. Prof. Dr. Snezhana Bakalova






Prof. Vanya Kurteva

Assoc. Prof. Irena Philipova

Assoc. Prof. Vanya Mantareva

Assoc. Prof. Ivan Angelov

Prof. Jose Kaneti

Dr. Nadezhda Tabakova

Meliha Aliosman

Nina Stoyanova

Vera Assenova

Prof. Han Zuilhof (WUR, NL)  

Prof. George Miloshev

Assoc. Prof. Milena Georgieva

Dr. Dessislava Staneva

Borislava Boteva

Bela Vasileva



Some ESIPT capable heterocyclic luminophores, used in the project

Obvious ESIPT candidates among the above molecules are only 1 and 2. 3 and 4 are internally hydrogen bound

even in their ground electronic states, while 5 and 6 are problematic. Nevertheless, the shown molecules are biologically

active due to a mechanism not involving hydrogen bonding. Literature data shows that this activity is possibly related to

association of quinazoline derivatives to specific nucleic acid secondary structures, guanine quadruplexes.


Our article on the above hypothesis has already been published in BBA-General subjects.

Two model drawings of a G4 complex with schizocommunin, molecule 3 above:

Our own computational and literature biological data are summarized in the following Table. Compound numbering is taken from the above Scheme, and the published article.



We are about to yield to the QSAR temptation... but there are a few more.:-)


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